Transition Metal-Catalyzed C-C Coupling Polycondensation.

Transition-Metal-Catalyzed C–H Functionalization for the Synthesis of Substituted Pyridines Transition-Metal-Catalyzed C–H Functionalization

SYNTHESIS 2011, No. 20, pp 3209–3219xx.xx.2011 Advanced online publication: 07.09.2011 DOI: 10.1055/s-0030-1260212; Art ID: E69311SS © Georg Thieme Verlag Stuttgart · New York Abstract: The direct functionalization of pyridine and related azine derivatives through carbon–carbon bond-forming reactions is reviewed. Various transformations that use a variety of transitionmetal catalysts are covere...

Recent Advances in Transition-Metal-Catalyzed, Directed Aryl C–H/N–H Cross-Coupling Reactions

Abstract Amination and amidation of aryl compounds using a transition-metal-catalyzed cross-coupling reaction typically involves prefunctionalization or preoxidation of either partner. In recent years, a new class of transition-metal-catalyzed cross-dehydrogenative coupling reaction has been developed for the direct formation of aryl C–N bonds. This short review highlights the substantial progr...

Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents To Construct C–C Bonds

Beyond Protecting Groups in Metal Catalyzed C–C Coupling: Direct Anomeric Propargylation of Aldoses

Since the seminal work of Butlerov (1863) 1a and Grignard (1900), the addition of preformed organometallic reagents to carbonyl compounds has played a central role in chemical synthesis. While this technology has opened vast volumes of chemical space, the basicity of most organometallic reagents mandates “protection” of acidic substructures, including the ubiquitous hydroxyl group. For the synt...

Transition Metal-Catalyzed C–C Bond Formation Reactions Using Alkyl Halides

This account reviews transition metal-catalyzed C–C bond formation reactions using alkyl halides, which have rarely been used as carbon sources in conventional transition metal-catalyzed systems. In the reactions, ate complexes formed by the reaction of transition metals with a Grignard reagent play important roles as the active catalytic species. The reactions mentioned here are mechanisticall...